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The effect of Vacor diabetes mellitus on the quadriceps muscle capillary basement membrane thickness has been examined by the electron microscopic method. With this procedure, it was possible to obtain an objective evaluation of the significance of capillary basement membrane thickening in Vacor diabetes mellitus. The results of such a study on the muscle capillary basement membrane in 10 normal subjects and 9 Vacor-poisoned patients have demonstrated the following: (1) the average basement membrane width of Vacor patients (2801 A +/- SD 614) is over twice that of normal subjects (1300 +/- 185 A), and all 9 cases demonstrated muscle capillary basement membrane thickening; (2) there is a significant association of basement membrane width with age (P less than 0.01), but not with the duration of the disease or fasting blood glucose values in the Vacor group. The results of the present study indicate that diabetes mellitus induced by Vacor poisoning can lead to microangiopathy, and that such basement membrane thickening is an early and consistent finding.
T H Lee, and
K C Choi, and
Y K Park, and
J K Choi
July 1986,
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T H Lee, and
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J K Choi
May 1976,
Diabetes,
T H Lee, and
K C Choi, and
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J K Choi
March 1981,
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T H Lee, and
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January 1999,
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February 2010,
Ultrastructural pathology,
T H Lee, and
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May 2021,
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T H Lee, and
K C Choi, and
Y K Park, and
J K Choi
January 1986,
Histology and histopathology,
T H Lee, and
K C Choi, and
Y K Park, and
J K Choi
December 1987,
Diabetologia,
T H Lee, and
K C Choi, and
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J K Choi
January 1966,
Transactions of the Association of American Physicians,
T H Lee, and
K C Choi, and
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J K Choi
November 1983,
Investigative ophthalmology & visual science,
