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The glycoprotein hormone erythropoietin regulates the level of oxygen in the blood by modulating the number of circulating erythrocytes, and is produced in the kidney or liver of adult and the liver of fetal or neonatal mammals. Neither the precise cell types that produce erythropoietin nor the mechanisms by which the same or different cells measure the circulating oxygen concentration and consequently regulate erythropoietin production are known. Cells responsive to erythropoietin have been identified in the adult bone marrow, fetal liver or adult spleen. In cultures of erythropoietic progenitors, erythropoietin stimulates proliferation and differentiation to more mature red blood cells. Detailed molecular studies have been hampered, however, by the impurity and heterogeneity of target cell populations and the difficulty of obtaining significant quantities of the purified hormone. Highly purified erythropoietin may be useful in the treatment of various forms of anaemia, particularly in chronic renal failure. Here we describe the cloning of the human erythropoietin gene and the expression of an erythropoietin cDNA clone in a transient mammalian expression system to yield a secreted product with biological activity.
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
October 1988,
Proceedings of the National Academy of Sciences of the United States of America,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
June 1996,
Biochimica et biophysica acta,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
July 1985,
FEBS letters,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
July 1995,
Journal of neurochemistry,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
June 1983,
Proceedings of the National Academy of Sciences of the United States of America,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
December 1991,
Plant molecular biology,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
April 1984,
The Journal of biological chemistry,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
November 1987,
Proceedings of the National Academy of Sciences of the United States of America,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
November 1982,
Proceedings of the National Academy of Sciences of the United States of America,
K Jacobs, and
C Shoemaker, and
R Rudersdorf, and
S D Neill, and
R J Kaufman, and
A Mufson, and
J Seehra, and
S S Jones, and
R Hewick, and
E F Fritsch
May 1990,
Brain research. Molecular brain research,
