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A study was made of metronidazole accumulation in the blood of animals and tumorous tissues of Pliss lymphosarcoma after the total moderate hyperthermia caused by subcutaneous injection of the pyrogenic drug sulfadiazine. Metronidazole concentration in the blood and tumors of hyperthermized animals was 2-3 times as high as in those of the control animals. A time shift of the maximum values of metronidazole accumulation occurred in hyperthermia. Under normal conditions the peak of accumulation was observed 2 h after the administration of the radiosensitizer whereas in hyperthermia depending on its duration it could develop 1 h earlier. Thus the total moderate hyperthermia served as a favorable background for raising metronidazole concentration in tumor opening up prospects for potentiating the radiosensitizing effect of metronidazole and perhaps some other means in the utilization of small nontoxic doses of the drug.
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
November 1995,
Cancer research,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
June 1984,
Radiation research,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
January 1982,
Progress in clinical and biological research,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
January 1988,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
December 1980,
Electroencephalography and clinical neurophysiology,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
November 1995,
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
May 1980,
Medical & biological engineering & computing,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
August 1986,
Thrombosis research,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
January 1982,
Advances in experimental medicine and biology,
G D Seĭtkazina, and
M L Efimov, and
R P Koposova
May 2002,
Acta anaesthesiologica Scandinavica,
