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Ninety-five children with localized Ewing's sarcoma were included in a prospective cooperative study. All patients received initial chemotherapy with the purpose of early prevention of metastases and improvement of the conditions of the subsequent local therapy, radiotherapy in all cases, surgical resection in selected cases. Clinical response to initial chemotherapy was evaluated in 67 patients who had measurable soft tissue mass or functional symptoms. This response appeared highly correlated with outcome as the disease-free survival was 57.3% for the 41 good responders and 9% for the 26 bad responders (P less than 0.00001), though 23 of these bad responders reached complete remission with radiotherapy. This study also confirms the prognostic significance for survival of the site of the primary tumor on axial skeleton or on limbs. Nevertheless, this factor had no predictive value for response to chemotherapy, which thus appears to be an independent factor.
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
April 1997,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
December 1985,
European journal of cancer & clinical oncology,
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
July 1988,
International journal of radiation oncology, biology, physics,
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
September 1993,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
August 1983,
Cancer,
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
October 2010,
Indian journal of orthopaedics,
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
September 1974,
Revue de stomatologie et de chirurgie maxillo-faciale,
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
January 1998,
Acta oncologica (Stockholm, Sweden),
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
December 1972,
Cancer,
O Oberlin, and
C Patte, and
F Demeocq, and
M J Lacombe, and
M Brunat-Mentigny, and
M C Demaille, and
P Tron, and
B N'Guyen Bui, and
J Lemerle
September 2015,
The West Indian medical journal,
