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Spinal astroblastoma, MN1 altered in 3-year-old child: An uncommon tumor at an unusual site. 2024

Arun Kumar Panda, and Sumanta Das, and Anuj Singh, and Sandeep Vaishya, and Rakesh Kumar Gupta, and Mehar Chand Sharma, and Sunita Ahlawat
Department of Pathology, Agilus Diagnostics Ltd-Fortis Memorial Research Institute (FMRI), Gurugram, India.

Astroblastoma is an uncommon circumscribed glial tumor mostly involving the cerebral hemisphere. The characteristic molecular alteration is meningioma (disrupted in balanced translocation) 1 (MN1) rearrangement. No definite World Health Organization grade has been assigned as both low- and high-grade tumors are known to occur. Tumors in the spine are extremely rare; to date only three cases have been reported in the literature. A vigilant microscopy and ancillary testing aid in diagnosis when the tumors present in unusual locations, as in our case. The prompt differentiation of this tumor from its mimickers is a mandate as modalities of management are different and not clearly established.

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