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Immunologic predictors of vaccine responsiveness in patients with lymphoma and CLL. 2024
Elise A Chong, and
Kingsley Gideon Kumashie, and
Emeline R Chong, and
Joseph Fabrizio, and
Aditi Gupta, and
Jakub Svoboda, and
Stefan K Barta, and
Kristy M Walsh, and
Ellen B Napier, and
Rachel K Lundberg, and
Sunita D Nasta, and
James N Gerson, and
Daniel J Landsburg, and
Joyce Gonzalez, and
Andrew Gaano, and
Madison E Weirick, and
Christopher M McAllister, and
Moses Awofolaju, and
Gavin N John, and
Shane C Kammerman, and
Josef Novaceck, and
Raymone Pajarillo, and
Kendall A Lundgreen, and
Nicole Tanenbaum, and
Sigrid Gouma, and
Elizabeth M Drapeau, and
Sharon Adamski, and
Kurt D'Andrea, and
Ajinkya Pattekar, and
Amanda Hicks, and
Scott Korte, and
Harsh Sharma, and
Sarah Herring, and
Justine C Williams, and
Jacob T Hamilton, and
Paul Bates, and
Scott E Hensley, and
Eline T Luning Prak, and
Allison R Greenplate, and
E John Wherry, and
Stephen J Schuster, and
Marco Ruella, and
Laura A Vella
The Richard Berman Family Innovations Center in CLL and Lymphomas, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, and the optimal timing of vaccination relative to therapy remains unknown. SARS-CoV-2 vaccines created an opportunity for new insights in vaccine timing because patients were challenged with a novel antigen across multiple phases of treatment. We studied serologic mRNA vaccine response in retrospective and prospective cohorts with lymphoma and CLL, paired with clinical and research immune parameters. Reduced serologic response was observed more frequently during active therapies, but non-response was also common within observation and post-treatment groups. Total IgA and IgM correlated with successful vaccine response. In individuals treated with CART-19, non-response was associated with reduced B and T follicular helper cells. Predictors of vaccine response varied by disease and therapeutic group, and therefore further studies of immune health during and after cancer therapies are needed to allow individualized vaccine timing.
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