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The peptide, succinyl-alanyl-alanyl-prolyl-valine chloromethylketone (SPCK), a synthetic inhibitor of elastase, was covalently attached to human albumin microspheres (HAM) and administered intratracheally to hamsters 15 min and 8 h prior to the instillation of porcine pancreatic elastase. Pressure-volume relationships and histologic examination of excised lungs after 4 wk showed complete protection from emphysema when SPCK-HAM was administered either 15 min or 8 h before elastase exposure. Concurrent experiments with free SPCK showed that protection was achieved only if elastase was administered within 15 min after the instillation of SPCK. Extending this period to 8 h not only led to a failure of free SPCK to prevent emphysema but actually resulted in more extensive air-space enlargement. The prolonged effectiveness conferred by the attachment of SPCK to a biodegradable carrier should reduce the frequency with which it would have to be administered for the therapeutic intervention of emphysema and should minimize any toxic side reactions.
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
August 1983,
European journal of respiratory diseases,
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
June 1980,
The American review of respiratory disease,
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
January 1980,
Bulletin europeen de physiopathologie respiratoire,
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
January 1991,
Annals of the New York Academy of Sciences,
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
January 1986,
Experimental lung research,
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
January 1991,
Annals of the New York Academy of Sciences,
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
March 1999,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
January 1991,
Experimental lung research,
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
May 1979,
Proceedings of the National Academy of Sciences of the United States of America,
S R Gudapaty, and
I E Liener, and
J R Hoidal, and
R V Padmanabhan, and
D E Niewoehner, and
J Abel
April 1982,
The American review of respiratory disease,
