-transparent.png){kind=logo}
The effect of adenosine-5'-(N-ethylcarboxamide) (744-96), a highly vasoactive adenosine analogue, was investigated on insulin and glucagon release from isolated rat islets of Langerhans. The compound inhibited glucose-induced insulin release in a dose-dependent manner (concentration range 10(-8) to 10(-5 M). No effect of 744-96 was observed on basal or on arginine-induced glucagon release. By contrast, 744-96 (5 microgram/kg i.v.) produced a significant increase in plasma glucagon and glucose levels in normal as well as in reserpinized rats. The observed failure to promote glucagon release from isolated islets may be attributable to the isolation procedure, to a release of glucagon in vivo from non-pancreatic stores, or to a non-specific effect of 744-96 on glucagon secretion.
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
February 1969,
Metabolism: clinical and experimental,
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
April 1968,
Diabetes,
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
June 1969,
Diabetes,
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
January 1968,
Diabetes,
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
September 1968,
The Biochemical journal,
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
February 1973,
Diabetes,
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
November 1975,
Biochemical and biophysical research communications,
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
February 1977,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
August 1969,
Archives internationales de physiologie et de biochimie,
W Schütz, and
G Raberger, and
G Brugger, and
O Kraupp
March 1971,
The Biochemical journal,
