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Pathogenic Potential of Eomesodermin-Expressing T-Helper Cells in Neurodegenerative Diseases. 2024
Tomomi Kanazawa, and
Wakiro Sato, and
Ben J E Raveney, and
Daiki Takewaki, and
Atsuko Kimura, and
Hiromi Yamaguchi, and
Yuma Yokoi, and
Reiko Saika, and
Yuji Takahashi, and
Tsuneo Fujita, and
Shinji Saiki, and
Akira Tamaoka, and
Shinji Oki, and
Takashi Yamamura
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Eomesodermin-expressing (Eomes+) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes+ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes+ Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024.
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