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The preclinical and phase 1 development of the novel oral cathepsin C inhibitor BI 1291583. 2024
James D Chalmers, and
Philipp Badorrek, and
Claudia Diefenbach, and
Harald Kögler, and
Wiebke Sauter, and
Stefan Kreideweiss, and
Jens M Hohlfeld
Division of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.
Preclinical and phase 1 study results indicate that BI 1291583 is a reversible, highly potent and highly selective CatC inhibitor that markedly inhibits active NSP production in a dose-dependent manner, supporting phase 2 trials in bronchiectasis patients https://bit.ly/47PZ8E5.
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