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The gestational time of appearance of gastrin and somatostatin in the human fetal stomach, duodenum and pancreas was examined. Immunoreactive gastrin (IRG) is detected in antral, duodenal and pancreatic extracts of a 7.0-cm (crown-heel length) fetus. More IRG is extracted from the duodenum than the antrum. Duodenal IRG concentration from fetuses of 16.0--26.0 cm are higher than younger fetal and adult concentrations. Antral IRG concentrations are one tenth of the adult contents. Very small IRG concentrations are present in the human fetal pancreas. Gastrin immunohistochemical staining is positive first in duodenal (6.5-cm fetus) and later in antral (12.5-cm fetus) mucosa; pancreatic tissue is negative for gastrin immunohistochemistry. Type IV cells are encountered in antral and duodenal mucosa of 4.0-cm fetuses; other endocrine cells appear with fetal growth. Not until much later in gestation (21.0 cm) do typical G cells appear. These results suggest that early in fetal life gastrin is produced by the type IV cell. Somatostatin immunohistochemical staining is positive in stomach, duodenum and pancreas in 6.5-cm fetuses. Immature D cells are found in antral and duodenal mucosa of 5.0-cm fetuses and mature D cells in 11.0-cm fetuses.
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
August 1987,
The Anatomical record,
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
January 1988,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
January 1974,
American journal of surgery,
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
December 1953,
Acta gastro-enterologica Belgica,
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
June 1995,
Vnitrni lekarstvi,
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
January 1980,
Scandinavian journal of gastroenterology,
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
September 1986,
Klinicheskaia meditsina,
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
January 1987,
Terapevticheskii arkhiv,
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
November 1965,
Lancet (London, England),
N S Track, and
C Creutzfeldt, and
J Litzenberger, and
C Neuhoff, and
R Arnold, and
W Creutzfeldt
January 2003,
Hepato-gastroenterology,
