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An aberrant leukemic clone with a 46,X,i(Xq) karyotype appeared at the first relapse of the disease in a case of acute myeloblastic leukemia (AML). The DNA replication pattern displayed asynchronous late termination within the homologous arms of the isochromosome in all investigated metaphases. The origin of asynchrony in the isochromosome's DNA replication pattern is discussed.
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