-transparent.png){kind=logo}
To determine the release and absorption profile of prostaglandin E2 from a new vaginal film formulation containing 850 micrograms PGE2, serial plasma levels of 13,14-dihydro-15-keto PGE2 were measured by radioimmunoassay in pregnant women between 16 and 18 weeks gestation. A control group, using placebo vaginal film was included in the study. There was a somewhat uniform increase in the plasma levels of the PGE2 metabolite, reaching peak levels between 4 and 6 hours after application of the film. The findings suggest that this drug formulation could be used clinically when slow constant release of the prostaglandin is required over a period of hours such as in pre-induction cervical ripening of term pregnancy.
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
June 1980,
Prostaglandins,
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
January 1982,
Methods in enzymology,
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
August 1984,
Prostaglandins,
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
July 1979,
Archives of gynecology,
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
January 1980,
Advances in prostaglandin and thromboxane research,
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
January 1982,
Methods in enzymology,
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
January 1977,
Prostaglandins,
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
October 1986,
Prostaglandins,
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
December 1974,
Lancet (London, England),
R N Prasad, and
A C Roy, and
S R Kottegoda, and
S S Ratnam, and
S M Karim
March 1984,
Prostaglandins, leukotrienes, and medicine,
