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Cytological and cytogenetic studies on 17 acute myelomonocytic leukemia with bone marrow eosinophilia (M4EO) are reported. Cytological criteria include an unusual high proportion of eosinophilic cells containing abnormal granules. Abnormal karyotypes have been found in 12 patients but chromosome 16 abnormalities were present in only 9. In two of them only one such mitosis was detected whereas in 7 others inv(16)(p13q22) and/or del (16)(q22) clones were present. However in 16 cases normal karyotypes were also present. Other abnormal clones coexisted in three patients, suggesting that chromosome 16 abnormalities are not linked to a primary leukemogenic event. M4EO was found to be associated with a favourable prognosis.
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
September 1988,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
October 1986,
Cancer genetics and cytogenetics,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
June 1972,
British journal of haematology,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
January 1998,
Ryoikibetsu shokogun shirizu,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
May 1989,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
February 1986,
Cancer genetics and cytogenetics,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
December 1987,
Cancer genetics and cytogenetics,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
February 1986,
The Indian journal of medical research,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
June 1961,
British medical journal,
R Berger, and
A Bernheim, and
M T Daniel, and
F Valensi, and
F Sigaux, and
G Flandrin
November 1971,
Acta medica Scandinavica,
