Biomaterial Database

Serum antibodies against oral Streptococcus mutans in young children in relation to dental caries and maternal close-contacts. 1985

A S Aaltonen, and J Tenovuo, and O P Lehtonen, and R Saksala, and O Meurman

Thirty-six children aged 2.6-4.9 years were studied with respect to dental caries, Streptococcus mutans counts in dental plaque, and the estimates of total amount and avidity of serum IgG, IgM and IgA antibodies against Strep. mutans 10449, serotype c. A significant positive correlation (r = 0.49, p less than 0.01) was found between the number of Strep. mutans and caries-index in children. Two children with dental caries had no oral Strep. mutans. In median tests, high antibody titre and avidity of serum IgG antibodies against Strep. mutans were associated (p less than 0.05) with low counts of Strep. mutans. No such relationship was found with IgM or IgA antibodies. Children who had had frequent maternal close-contacts in their first year had significantly more (p less than 0.05) IgG antibodies against Strep. mutans than children with rare close-contacts.

UI	MeSH Term	Description	Entries
D007136	Immunoglobulins	Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.	Globulins, Immune,Immune Globulin,Immune Globulins,Immunoglobulin,Globulin, Immune
D009034	Mother-Child Relations	Interaction between a mother and child.	Mother-Child Interaction,Mother-Child Relationship,Mother-Infant Interaction,Mother-Infant Relations,Interaction, Mother-Child,Interaction, Mother-Infant,Interactions, Mother-Child,Interactions, Mother-Infant,Mother Child Interaction,Mother Child Relations,Mother Child Relationship,Mother Infant Interaction,Mother Infant Relations,Mother-Child Interactions,Mother-Child Relation,Mother-Child Relationships,Mother-Infant Interactions,Mother-Infant Relation,Relation, Mother-Child,Relation, Mother-Infant,Relations, Mother-Child,Relations, Mother-Infant,Relationship, Mother-Child,Relationships, Mother-Child
D001942	Breast Feeding	The nursing of an infant at the breast.	Breast Fed,Breastfed,Milk Sharing,Wet Nursing,Breast Feeding, Exclusive,Breastfeeding,Breastfeeding, Exclusive,Exclusive Breast Feeding,Exclusive Breastfeeding,Sharing, Milk
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003731	Dental Caries	Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	Caries, Dental,Carious Lesions,Dental Cavities,Dental Cavity,Dental Decay,Dental White Spots,Carious Dentin,Decay, Dental,Dental White Spot,White Spot, Dental,White Spots, Dental,Carious Dentins,Carious Lesion,Cavities, Dental,Cavity, Dental,Dentin, Carious,Dentins, Carious,Lesion, Carious,Lesions, Carious,Spot, Dental White,Spots, Dental White
D003773	Dental Plaque	A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.	Plaque, Dental
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000907	Antibodies, Bacterial	Immunoglobulins produced in a response to BACTERIAL ANTIGENS.	Bacterial Antibodies
D013295	Streptococcus mutans	A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.