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Contemporary Insights into Intractable Epilepsy in Children. 2024

Khaled Saad, and Emad H Eldaly, and Hazem M Abdelall, and Nahed M Abdelgabaar, and David M Zaki, and Hamad G Dailah, and Ahmed Shams-Eldeen, and Khalid H Mahmoud
Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.

While most children with epilepsy find their seizures manageable through medication, some continue to experience seizures despite trying multiple drugs. Failure of medical treatment often becomes apparent early on, and for these cases, it is advisable to seek further treatment options at a specialized epilepsy center. Such centers offer additional treatments like epilepsy surgery, vagus nerve stimulation, and ketogenic diets. There is no universal definition for what constitutes "medically intractable" epilepsy. A proposal by a task force from the International League Against Epilepsy suggests that drug-resistant epilepsy could be defined as the inability to control seizures even after two adequate treatment attempts with well-chosen and tolerated medications, either alone or in combination. In this review, the authors discussed the management of intractable epilepsy in children.

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