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Effect of inactive precursor of alpha-thrombin--prethrombin (Pre-I) and prostaglandin (PGE2) on aggregation of washed rat platelets induced by alpha-thrombin was studied. Pre-I inhibited dose-dependently the alpha-thrombin-induced platelet aggregation. K1 values for Pre-I of high and low affinity binding sites were equal to 0.9.10(-8) M and 0.56.10(-6) M, respectively. PGE2 inhibited the alpha-thrombin-induced aggregation after simultaneous addition and within 5 and 15 min of incubation with PGE2. Preincubation of platelets with alpha-thrombin within 15 min prevented the PGE2-induced aggregation but preincubation of platelets with Pre-I within 15 min did not influence the platelet aggregation, induced by PGE2.
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
January 1972,
Prostaglandins,
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
May 1992,
Agents and actions,
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
October 1996,
Journal of leukocyte biology,
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
November 1986,
Thrombosis research,
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
January 1978,
Research communications in chemical pathology and pharmacology,
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
January 1992,
Biokhimiia (Moscow, Russia),
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
January 1992,
Acta haematologica Polonica,
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
June 2007,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
November 1994,
Prostaglandins, leukotrienes, and essential fatty acids,
S M Strukova, and
L N Petrova, and
E G Kireeva, and
G V Rtishcheva, and
V S Liubimov
December 1975,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
