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Eight immunosuppressed patients had pneumonia due to Pittsburgh Pneumonia Agent (PPA), a gram-negative, weakly acid-fast bacterium cultivatable only in embryonated eggs and guinea pigs and distinct from Legionella pneumophila. The diagnosis was established by isolation of the agent from lung or visualization of the organism in lung tissue. The clinical presentations, radiographic abnormalities and pathology were not specific. The most consistent feature associated with the disease was the recent institution of daily high-dose corticosteriod therapy in all patients. Five of the eight patients died despite broad-spectrum antibiotic and antituberculous therapy. Anti-microbial activity against PPA was demonstrated for sulfamethoxazole combined with trimethoprim, for rifampin and for erythromycin with an egg-protection assay. Serologic studies with an indirect fluorescent-antibody technic suggested that seroconversion or high titers may be a sensitive test for PPA disease. PPA appears to be a newly recognized cause of life-threatening bacterial pneumonia in immunosupressed patients.
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
January 1980,
Duodecim; laaketieteellinen aikakauskirja,
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
March 1981,
The Journal of urology,
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
March 1983,
Medicine,
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
January 1983,
Scandinavian journal of infectious diseases,
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
November 1981,
Lancet (London, England),
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
March 1984,
Radiology,
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
October 1980,
Medicina clinica,
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
February 1982,
AJR. American journal of roentgenology,
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
November 1981,
British medical journal (Clinical research ed.),
R L Myerowitz, and
A W Pasculle, and
J N Dowling, and
G J Pazin, and
M Puerzer, and
R B Yee, and
C R Rinaldo, and
T R Hakala
December 1987,
Seminars in respiratory infections,
