Biomaterial Database

Steroid-cyclophosphamide pretreatment of kidney allograft donors. A control study. 1979

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

34 cadaveric donor grafts were randomized in a blind study of the effect of pretreatment of 5 g each of methylprednisolone and cyclophosphamide on kidney graft outcome. There was no difference in overall survival or functioning after 3, 6 or 12 months between grafts from pretreated (33 kidneys) or control (29 kidneys) cadaveric donors. In addition, this pretreatment protocol did not modify the recipient immune response against B-lymphocyte alloantigens which developed in unsuccessful transplants. Our data, thus, neither confirm the high rate of kidney graft survival attributed to cadaveric donor treatment nor the supposition that treatment is effective in suppressing recipient antidonor B-lymphocyte antibodies.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008775	Methylprednisolone	A PREDNISOLONE derivative with similar anti-inflammatory action.	6-Methylprednisolone,Medrol,Metipred,Urbason,6 Methylprednisolone
D011292	Premedication	Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.	Premedications
D002102	Cadaver	A dead body, usually a human body.	Corpse,Cadavers,Corpses
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D003520	Cyclophosphamide	Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.	(+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate,B-518,Cyclophosphamide Anhydrous,Cyclophosphamide Monohydrate,Cyclophosphamide, (R)-Isomer,Cyclophosphamide, (S)-Isomer,Cyclophosphane,Cytophosphan,Cytophosphane,Cytoxan,Endoxan,NSC-26271,Neosar,Procytox,Sendoxan,B 518,B518,NSC 26271,NSC26271
D005260	Female		Females
D006085	Graft Survival	The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.	Graft Survivals,Survival, Graft,Survivals, Graft
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

Steroid pretreatment of organ donors to prevent postischemic renal allograft failure: a randomized, controlled trial.

August 2010, Annals of internal medicine,

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

Kidney allograft failure in the steroid-free immunosuppression era: A matched case-control study.

November 2017, Clinical transplantation,

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

Aprotinin for the pretreatment of liver allograft donors.

June 1990, Transplantation,

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

Steroid pretreatment of organ donors does not impact on early rejection and long-term kidney allograft survival: Results from a multicenter randomized, controlled trial.

June 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

Manipulation of allograft immunogenicity by pretreatment of cadaver donors.

October 1976, The Urologic clinics of North America,

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

The effect of steroid pretreatment of deceased organ donors on liver allograft function: a blinded randomized placebo-controlled trial.

June 2012, Journal of hepatology,

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

Dopamine pretreatment in unstable kidney donors.

February 1979, British medical journal,

J P Soulillou, and D Baron, and A Rouxel, and J Guenel

Steroid pretreatment of deceased donors and liver allograft function - Ten years follow-up of a blinded randomized placebo controlled trial.

October 2021, International journal of surgery (London, England),