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Ofloxacin (OFLX) in a single dose (250 or 2500 mg/kg) or 5 consecutive daily doses (125 or 1250 mg/kg) produced no dominant lethal mutational effects in male BDF1 strain mice during an 8-week mating schedule. Methyl methanesulfonate (MMS), used as a positive control, produced dominant lethal mutations within 1-3 weeks of mating.
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