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4-Demethoxydaunorubicin (4-DMDR) is an orally active analog of daunorubicin that in preclinical testing has demonstrated greater antitumor activity and less cardiotoxicity than its parent compound. Thirty-two patients with metastatic non-small cell lung cancer received 4-DMDR at a dose of 40-50 mg/m2 orally every 21 days. Thirteen patients had received no prior chemotherapy. Among the 30 adequately treated patients, one major response lasting 5.2 months was observed. Leukopenia 10-14 days after treatment was the most commonly observed toxicity. With an overall observed major response rate of 3.3% in 30 patients, the predicted true response rate is less than or equal to 16% (p = 0.05). At the dose and schedule studied in this group of patients with non-small cell lung cancer, 4-DMDR had only marginal activity.
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
March 1984,
Cancer treatment reports,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
September 1988,
Investigational new drugs,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
January 1986,
Investigational new drugs,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
January 1987,
Cancer chemotherapy and pharmacology,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
January 1990,
Investigational new drugs,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
August 1986,
Onkologie,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
August 1991,
Investigational new drugs,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
September 1987,
Cancer treatment reports,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
November 1985,
Cancer treatment reports,
M G Kris, and
R J Gralla, and
D P Kelsen, and
E S Casper, and
M T Burke, and
J J Fiore, and
I R Cibas, and
R T Heelan
January 1988,
Cancer investigation,
