[Godwin's tumor and Gougerot-Sjögren syndrome. Apropos of 2 cases]. 1985

P Laudenbach, and M C Leygue, and J C Bertrand, and A Deboise, and A Vieillefond

Two new cases of pseudo-tumoral parotid benign lymphoepithelial lesion serve as the basis for a review of the clinical aspects of "Godwin tumour". This is a pseudo-tumoral parotid swelling of non-characteristic clinical appearance which has the radiological findings of a systemic type sialogram ("punctate marks" and diffuse parenchymatous spots). Histopathological examination shows lesions affecting the whole gland but predominant in the swollen area, sometimes surrounded by a connective tissue pseudo-capsule. These lesions are the same as those seen in Sjögren's syndrome. There are virtually no humoral immunological abnormalities such as auto-antibodies nor inflammatory laboratory abnormalities. Whilst the diagnosis of this rare condition may be considered in the presence of any isolated parotid swelling with a sialogram of systemic type, the diagnosis of a benign lymphoepithelial lesion, eliminating a lymphoma, can be made only by histopathological examination of the parotidectomy specimen. These lesions could be the pseudo-tumoral form of isolated, so-called primary, Sjögren's syndrome. Some of these isolated syndromes become more complete after several years with the appearance of auto-antibodies. Clinical, immunological and haematological surveillance of these benign lymphoepithelial lesions is thus necessary during the years following parotidectomy.

UI MeSH Term Description Entries
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010305 Parotid Diseases Diseases involving the PAROTID GLAND. Disease, Parotid,Diseases, Parotid,Parotid Disease
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012796 Sialography Radiography of the SALIVARY GLANDS or ducts following injection of contrast medium. Sialographies
D012859 Sjogren's Syndrome Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis. Sicca Syndrome,Sjogren Syndrome,Sjogrens Syndrome,Syndrome, Sicca,Syndrome, Sjogren's

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