Biomaterial Database

[Positron emission tomography of regional extravascular lung water and regional pulmonary blood volume in chronic heart failure]. 1985

C Bossaller, and O Schober, and G J Meyer, and H Hundeshagen, and P R Lichtlen

In 6 controls (group A), 4 patients with moderate congestive heart failure (NYHA II, II-III: group B) and 6 patients with severe heart failure (NYHA III, III-IV, IV: group C) regional lung water (rLW, constant infusion of H2 15O), regional pulmonary blood volume (rPBV, inhaled 11CO) and regional extravascular lung water (rELW = rLW -rPBV) were measured by positron emission tomography. The mean rELW was 0.12 +/- 0.02 g/cm3 in group A, 0.15 +/- 0.03 g/cm3 in group B and 0.19 +/- 0.06 g/cm3 in group C. In group C a significant increase in rELW was found from cranial to caudal regions (p less than 0.005), whereas in controls the distribution of rELW was almost homogeneous. The mean rPBV was 0.21 +/- 0.04 g/cm3 in group A, 0.22 +/- 0.04 g/cm3 in group B, and 0.17 +/- 0.03 g/cm3 in group C. There was a progressive increase in rPBV from cranial to caudal in group A. In group C the distribution of rPBV was almost uniform showing, compared to group A, significant lower values in the caudal regions (p less than 0.01). The study suggests that the amount and distribution of fluid in pulmonary congestion can be assessed noninvasively by positron emission tomography and that substantial differences in regional distribution exist between controls and patients with congestive heart failure.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010104	Oxygen Radioisotopes	Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.	Radioisotopes, Oxygen
D011652	Pulmonary Circulation	The circulation of the BLOOD through the LUNGS.	Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D011654	Pulmonary Edema	Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	Wet Lung,Edema, Pulmonary,Edemas, Pulmonary,Pulmonary Edemas,Lung, Wet,Lungs, Wet,Wet Lungs
D001810	Blood Volume	Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.	Blood Volumes,Volume, Blood,Volumes, Blood
D002250	Carbon Radioisotopes	Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.	Radioisotopes, Carbon
D005110	Extracellular Space	Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.	Intercellular Space,Extracellular Spaces,Intercellular Spaces,Space, Extracellular,Space, Intercellular,Spaces, Extracellular,Spaces, Intercellular
D005260	Female		Females