BIOMAT Database Logo BIOMAT Database Logo

In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomography. 1985

D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden

In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using [11C]dimethyloxazolidinedione [( 11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our results, which are consistent with reported [14C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more "acidic" than that of normal gray or white matter.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010080 Oxazoles Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions. Oxazole,1,3-Oxazolium-5-Oxides,Munchnones,1,3 Oxazolium 5 Oxides
D001932 Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. Brain Cancer,Brain Metastases,Brain Tumors,Cancer of Brain,Malignant Primary Brain Tumors,Neoplasms, Intracranial,Benign Neoplasms, Brain,Brain Neoplasm, Primary,Brain Neoplasms, Benign,Brain Neoplasms, Malignant,Brain Neoplasms, Malignant, Primary,Brain Neoplasms, Primary Malignant,Brain Tumor, Primary,Brain Tumor, Recurrent,Cancer of the Brain,Intracranial Neoplasms,Malignant Neoplasms, Brain,Malignant Primary Brain Neoplasms,Neoplasms, Brain,Neoplasms, Brain, Benign,Neoplasms, Brain, Malignant,Neoplasms, Brain, Primary,Primary Brain Neoplasms,Primary Malignant Brain Neoplasms,Primary Malignant Brain Tumors,Benign Brain Neoplasm,Benign Brain Neoplasms,Benign Neoplasm, Brain,Brain Benign Neoplasm,Brain Benign Neoplasms,Brain Cancers,Brain Malignant Neoplasm,Brain Malignant Neoplasms,Brain Metastase,Brain Neoplasm,Brain Neoplasm, Benign,Brain Neoplasm, Malignant,Brain Neoplasms, Primary,Brain Tumor,Brain Tumors, Recurrent,Cancer, Brain,Intracranial Neoplasm,Malignant Brain Neoplasm,Malignant Brain Neoplasms,Malignant Neoplasm, Brain,Neoplasm, Brain,Neoplasm, Intracranial,Primary Brain Neoplasm,Primary Brain Tumor,Primary Brain Tumors,Recurrent Brain Tumor,Recurrent Brain Tumors,Tumor, Brain
D002250 Carbon Radioisotopes Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes. Radioisotopes, Carbon
D004114 Dimethadione An anticonvulsant that is the active metabolite of TRIMETHADIONE. 5,5-Dimethyl-2,4-oxazolidinedione,5,5-Dimethyloxazolidine-2,4-dione,Dimethyloxazolidinedione
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
[11C-methionine positron emission tomography in brain tumor].
October 2008, No shinkei geka. Neurological surgery,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
Measurement of brain pH using 11CO2 and positron emission tomography.
March 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
Measurement of human blood brain barrier integrity using 11C-inulin and positron emission tomography.
January 1988, European journal of nuclear medicine,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
Positron Emission Tomography Imaging of Lesions pH Using 11C-Labeled Bicarbonate.
September 2018, Cancer biotherapy & radiopharmaceuticals,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
Brain tumor imaging by positron emission computed tomography using 11C-labeled amino acids.
June 1982, Journal of computer assisted tomography,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
[Positron emission tomography with 11C-methionine in primary brain tumor diagnosis].
January 2020, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
In vivo imaging of vesicular monoamine transporters in human brain using [11C]tetrabenazine and positron emission tomography.
June 1993, Journal of neurochemistry,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
Turnover of brain monoamine oxidase measured in vivo by positron emission tomography using L-[11C]deprenyl.
August 1987, Journal of neurochemistry,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
Discrepancies in brain tumor extent as shown by computed tomography and positron emission tomography using [68Ga]EDTA, [11C]glucose, and [11C]methionine.
December 1983, Journal of computer assisted tomography,
D A Rottenberg, and J Z Ginos, and K J Kearfott, and L Junck, and V Dhawan, and J O Jarden
[11C-methionine positron emission tomography in nontumorous brain lesions].
November 2010, No shinkei geka. Neurological surgery,
Copied contents to your clipboard!