-transparent.png){kind=logo}
The EMIT technique for theophylline measurement as adapted to the Abbott Bichromatic Analyzer (ABA-100), was compared to two other established procedures. EMIT results correlated well with those obtained with high pressure liquid chromatographic (HPLC) (r = 0.995, N = 54) and spectrophotometric (UV) (r = 0.95, N = 37) methods when the patient samples used were free of apparent interferences in the comparison methods. On samples exhibiting interferences with HPLC and/or UV methods, the EMIT assay gave the same results as a gas-liquid chromatographic procedure which showed no interferences. In addition, theophylline metabolites, xanthine analogs and many commonly administered drugs did not interfere with the EMIT theophylline assay. An interassay coefficient of variation of 3.5--6.5% was demonstrated. Our data indicate that the EMIT technique exhibits adequate precision and specificity for routine theophylline determinations. Unlike the HPLC or UV procedures, we have not encountered any interferences with the EMIT technique.
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
January 1977,
Clinical chemistry,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
January 1982,
Journal of analytical toxicology,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
March 1978,
Clinical chemistry,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
July 1977,
The New England journal of medicine,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
April 1979,
Clinical biochemistry,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
April 1978,
Clinical biochemistry,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
January 1978,
Forensic science,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
January 1979,
Veterinary and human toxicology,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
January 1988,
Therapeutic drug monitoring,
N Weidner, and
J M McDonald, and
V L Tieber, and
C H Smith, and
G Kessler, and
J H Ladenson, and
D N Dietzler
December 1998,
Transplantation proceedings,
