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Investigations on the chemotaxis of polymorphonuclear neutrophils (PMNs) towards a cytoplasmic extract of Trichophyton rubrum in the presence and absence of antifungal drugs are described. It is shown that with griseofulvin, clotrimazole, econazole, ketoconazole, miconazole and natamycin at 1 mg l(-1), the number of PMNs migrating was significantly reduced. After 3 h of exposure to 10 mg l(-1), not one of the drugs tested had any discernable effect on the viability of the PMNs, or the complement. The anti-inflammatory activity of the drugs is discussed and whilst the chemosuppression of PMN chemotaxis may be an undesirable feature in a drug used to treat systemic mycoses, it is unlikely to have any adverse effect in the therapy of the dermatophytoses.
R R Davies, and
F Zaini
November 1973,
Sabouraudia,
R R Davies, and
F Zaini
September 1977,
Lancet (London, England),
R R Davies, and
F Zaini
June 2014,
Journal of applied biomaterials & functional materials,
R R Davies, and
F Zaini
June 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R R Davies, and
F Zaini
January 2012,
Immunobiology,
R R Davies, and
F Zaini
January 1991,
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology,
R R Davies, and
F Zaini
June 1985,
Revue du rhumatisme et des maladies osteo-articulaires,
R R Davies, and
F Zaini
January 1979,
International archives of allergy and applied immunology,
R R Davies, and
F Zaini
November 1993,
European journal of clinical investigation,
R R Davies, and
F Zaini
January 1974,
Immunological communications,
