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A total of 5217 middle ear fluid (MEF) samples obtained from 1203 children with otitis media, aged 3 months to 6 years, were studied for the presence of Branhamella catarrhalis (Br) between Oct. 1977 and Sept. 1981. Br grew in 10.2% of 3497 MEFs of acute otitis media (AOM), with almost the same frequency in the very first and subsequent attacks. During the first 4 years of life the percentage did not vary much; among older children it seemed to decrease. The overall prevalence of Br in AOM did not change during the study period. Br alone grew in 72.4% of acute MEFs with Br; with other bacteria the respective figure was 82.9% (p less than 0.001). Acute attacks with bilateral Br were found in 22.8% of attacks with Br. In 1720 non-acute MEFs obtained at postacute control visits, Br was isolated in only 7.0%. The proportion of beta-lactamase-producing strains among the 2419 otitis-Br strains tested in two laboratories of the two study regions showed an increase from 27.1% and 21.1% in 1980 to 57.6% and 38.6% in 1983, respectively (p less than 0.001).
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
March 1996,
The Annals of otology, rhinology, and laryngology,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
January 1987,
Reviews of infectious diseases,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
January 1986,
Drugs,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
January 1986,
Drugs,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
February 1983,
The Journal of pediatrics,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
July 1994,
Acta oto-laryngologica,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
January 1981,
Journal of clinical microbiology,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
May 1990,
The American journal of medicine,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
January 1983,
Pediatric infectious disease,
P Karma, and
T Virtanen, and
J Pukander, and
M Sipilä, and
J Luotonen, and
M Timonen, and
E Herva, and
P Grönroos
January 1986,
Drugs,
