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A randomized two-arm study was undertaken to determine relative tumoricidal effects of intra-arterial cis-diamminedichloroplatinum II (I/A-CDP) and high-dose methotrexate with citrovorum factor rescue (MTX-CF) in the treatment of the primary tumor in patients with osteosarcoma. Responses were evaluated by clinical, radiographic, angiographic, and pathologic parameters. Fifteen patients were randomized to receive MTX-CF and 15 to I/A-CDP. In the MTX-CF arm there were four responses (three complete responses, one partial response) whereas in the I/A CDP arm there were nine responses (seven complete responses, two partial responses). Two patients who failed MTX-CF and requested alternative treatment with I/A-CDP also responded. The total I/A-CDP response was 11/17.
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
August 1984,
Onkologie,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
December 1977,
Cancer treatment reports,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
July 1983,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
September 1978,
Cancer treatment reports,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
September 1980,
Harefuah,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
January 1980,
Therapeutic drug monitoring,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
June 1982,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
June 1985,
Cancer,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
February 1978,
Cancer treatment reports,
N Jaffe, and
R Robertson, and
A Ayala, and
S Wallace, and
V Chuang, and
T Anzai, and
A Cangir, and
Y M Wang, and
T Chen
January 1983,
Pediatric pharmacology (New York, N.Y.),
