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Twenty patients scheduled for elective coronary surgery received either propofol ('Diprivan') 1.5 mg/kg in emulsion or thiopentone 2 mg/kg for induction of anaesthesia. Vecuronium was used for neuromuscular blockade. Cardiovascular dynamics were recorded every minute until 6 min after intubation. Anaesthesia with propofol was accompanied by a reduction in arterial pressure, the decrease being severe in two patients. This was largely due to a decrease in systemic vascular resistance. Thiopentone anaesthesia resulted in a smaller decrease in arterial pressure, but a marked increase in arterial pressure followed endotracheal intubation. Although the absence of haemodynamic changes following intubation during propofol anaesthesia is advantageous to the ischaemic myocardium, this has to be balanced by the variable and sometimes severe reduction in arterial pressure that occurred on induction.
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
January 1985,
Postgraduate medical journal,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
February 1991,
Anaesthesia,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
August 1985,
Anaesthesia,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
March 1988,
Anaesthesia,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
April 1991,
Anaesthesia,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
January 1989,
European journal of clinical pharmacology,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
January 1976,
Acta anaesthesiologica Scandinavica,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
April 1983,
Acta anaesthesiologica Scandinavica,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
September 1980,
British journal of anaesthesia,
M R Patrick, and
I J Blair, and
R O Feneck, and
P S Sebel
May 1987,
Minerva anestesiologica,
