Biomaterial Database

Propofol ('Diprivan') for continuous intravenous anaesthesia. A comparison with methohexitone. 1985

N Mackenzie, and I S Grant

The properties of propofol in emulsion given by continuous intravenous infusion to spontaneously breathing patients have been studied. Forty premedicated patients were anaesthetized with propofol infusion supplemented by nitrous oxide in oxygen. Induction and maintenance were uniformly smooth with no excitatory effects. Dose-related cardiovascular and respiratory depression allowed easy control of anaesthetic depth by adjusting the infusion rate. The mean duration of infusion was 51 min and the mean infusion rate 0.26 mg/kg/min. Recovery times were clinically acceptable and complications minimal. An attempted comparative study involving the use of methohexitone was abandoned after 10 cases when the latter agent proved unsuitable for use in this manner. The findings suggest that propofol may well be the agent of choice for continuous intravenous anaesthesia.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008723	Methohexital	An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.	Methohexitone,Brevimytal Natrium,Brevital,Brietal,Brietal-Sodium,Methohexital Sodium,Methohexital, Monosodium Salt,Brietal Sodium,Monosodium Salt Methohexital,Natrium, Brevimytal,Sodium, Methohexital
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010636	Phenols	Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D004655	Emulsions	Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.	Emulsion
D005260	Female		Females
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths