Biomaterial Database

[Selective IgA deficiency in patients with systemic lupus erythematosus and rheumatoid arthritis]. 1985

S Kuştimur, and E Gülmezoğlu

In this study, antinuclear antibody (ANA), rheumatoid factor (RF) studied and IgA was determined with single radial immunodiffusion (RID) technic in the sera of 96 patients with systemic lupus erythematosus, 25 with rheumatoid arthritis and 100 normal individuals. In normal control group, the average level of IgA was found to be 212 mg/dl. In one patient (1: 100), IgA deficiency was detected with a level of 2.1 mg/dl, the average level of IgA in 96 patients with SLE was 320 +/- 16.25 mg/dl. In 3 patients of this group IgA deficiency was observed. According to this finding, the prevalence of IgA deficiency in the group of SLE ise 1: 32. This prevalence is higher than that of the normal population. The average level of IgA in 25 patients with RA 302.66 +/- 36.57 mg/dl. In this group we observed IgA deficiency only in one patient which means a prevalence of 1: 25, that is higher than the normal group. Reports indicate that the incidence of IgA deficiency in general populations may vary from 1: 400 up to 1: 3080. But in patients with SLE and RA, this may be encountered more frequently as we observed in our cases.

UI	MeSH Term	Description	Entries
D008180	Lupus Erythematosus, Systemic	A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.	Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D004406	Dysgammaglobulinemia	An immunologic deficiency state characterized by selective deficiencies of one or more, but not all, classes of immunoglobulins.	Dysgammaglobulinemias
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000974	Antibodies, Antinuclear	Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.	Anti-DNA Antibodies,Antibodies, Anti-DNA,Antinuclear Antibodies,Antinuclear Autoantibodies,Antinuclear Autoantibody,Antinuclear Factors,Antinuclear Antibody,Antinuclear Factor,Anti DNA Antibodies,Antibody, Antinuclear,Autoantibody, Antinuclear,Factor, Antinuclear
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis