Biomaterial Database

S-100 protein in normal, osteoarthrotic, and arthritic cartilage. 1985

W Mohr, and C Kuhn, and B Pelster, and D Wessinghage

Abteilung Pathologie, Universität Ulm, Federal Republic of Germany.

The occurrence of the S-100 protein was studied in normal and pathological cartilage from patients with osteoarthrosis and rheumatoid arthritis. In normal cartilage all cells of the different zones exhibit immunoreactivity for this protein. An identical distribution is observed in cases of osteoarthrosis and rheumatoid arthritis. Cellular pannus tissue usually is devoid of the S-100 protein. However, if chondroid metaplasia occurs in this tissue the cells become positive for the S-100 protein. From these results it is concluded that a chondroid metaplasia not only leads to a matrix comparable to cartilage but also contains cells that gain further characteristics of original chondrocytes.

UI	MeSH Term	Description	Entries
D009418	S100 Proteins	A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.	Antigen S 100,Nerve Tissue Protein S 100,S100 Protein,S-100 Protein,S100 Protein Family,Protein, S100,S 100 Protein
D002358	Cartilage, Articular	A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.	Articular Cartilage,Articular Cartilages,Cartilages, Articular
D006651	Histocytochemistry	Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.	Cytochemistry
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis
D015207	Osteoarthritis, Hip	Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.	Coxarthrosis,Osteoarthritis of the Hip,Osteoarthritis Of Hip,Coxarthroses,Hip Osteoarthritis,Osteoarthritis Of Hips