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Captopril, the competitive inhibitor of angiotensin-converting enzyme, is of considerable benefit in difficult-to-manage forms of hypertension. Its use has been associated with various untoward effects, but hepatic injury has not been widely reported. We treated a patient with captopril-associated cholestatic jaundice; a review of cases reported to the drug manufacturer and a review of the literature showed 13 additional cases of hepatic injury associated with captopril. In 9 of these the jaundice was categorized as cholestatic, and in 4 of the remaining 5 as mixed cholestatic-hepatocellular. These findings show that jaundice may be an idiosyncratic side effect of captopril, and that captopril-associated jaundice characteristically has strongly cholestatic features.
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
January 1991,
Journal of gastroenterology and hepatology,
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
January 1991,
Southern medical journal,
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
March 1984,
Drug intelligence & clinical pharmacy,
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
April 1992,
Medicina clinica,
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
December 1983,
British medical journal (Clinical research ed.),
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
January 2018,
American journal of therapeutics,
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
December 1986,
Minnesota medicine,
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
January 1980,
Cancer treatment reports,
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
December 1992,
Postgraduate medical journal,
J Rahmat, and
R L Gelfand, and
M C Gelfand, and
J F Winchester, and
G E Schreiner, and
H J Zimmerman
January 2000,
International journal of clinical practice,
