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A multivariate analysis of the prognostic factors was carried out with a Cox model on 1,139 patients with clinical Stage I + II Hodgkin's disease included in three controlled clinical trials. The following indicators had been prospectively registered: age, sex, systemic symptoms, erythrocyte sedimentation rate (ESR), number and sites of involved lymph node areas, histologic type, clinical stage, pattern of presentation, results of staging laparotomy when performed, as well as the date and type of treatment. A linear logistic analysis showed that most of the indicators are interrelated. This emphasizes the necessity of a multivariate analysis in order to assess the independent influence of each of them. The two main prognostic indicators for relapse-free survival are systemic symptoms and/or ESR and number of involved areas. The only significant factor for survival after relapse is age. Sex has a small but significant influence on relapse-free survival. The relative influence of each indicator varies with the type of treatment and these variations may help in understanding the biologic significance of the indicators.
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M Henry-Amar, and
B van der Werf-Messing, and
J Henry, and
J Abbatucci, and
M Burgers, and
M Hayat, and
R Somers, and
A Laugier, and
P Carde
October 1986,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
M Tubiana, and
M Henry-Amar, and
B van der Werf-Messing, and
J Henry, and
J Abbatucci, and
M Burgers, and
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R Somers, and
A Laugier, and
P Carde
January 1997,
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P Carde
January 1989,
Neoplasma,
M Tubiana, and
M Henry-Amar, and
B van der Werf-Messing, and
J Henry, and
J Abbatucci, and
M Burgers, and
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A Laugier, and
P Carde
May 1982,
International journal of radiation oncology, biology, physics,
M Tubiana, and
M Henry-Amar, and
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P Carde
March 2000,
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P Carde
October 1988,
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M Tubiana, and
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P Carde
April 1982,
Cancer treatment reports,
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P Carde
September 1980,
Cancer,
