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The concentration of immunoreactive insulin (IRI) extracted from the olfactory bulb, hypothalamus, hippocampus, cerebral cortex, amygdala, midbrain, and hindbrain was significantly lower in obese (fa/fa) and heterozygous (Fa/fa) Zucker rats in comparison to lean (Fa/Fa) Zucker rats. This deficit in brain IRI content was most severe in the hypothalamus and olfactory bulb and was independent of severe obesity since the marked reduction of brain IRI content was also found in heterozygous rats which possessed only one copy of the fa allele. These results demonstrate that in the 2-3 month-old female Zucker rat, the fa allele is associated with defective regulation of insulin in the brain.
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
January 1990,
Peptides,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
October 1992,
Physiology & behavior,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
January 1989,
Peptides,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
December 1981,
Biochemical Society transactions,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
November 1982,
Pharmacology, biochemistry, and behavior,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
March 1991,
Experimental and clinical endocrinology,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
November 1990,
International journal of obesity,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
April 1985,
Endocrinology,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
May 1972,
Endocrinology,
D G Baskin, and
L J Stein, and
H Ikeda, and
S C Woods, and
D P Figlewicz, and
D Porte, and
M R Greenwood, and
D M Dorsa
January 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
