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An inhibitor and stimulator of CFU-s proliferation can be obtained from haemopoietic tissue containing, respectively, relatively quiescent CFU-s (e.g. normal bone marrow) and proliferating CFU-s (e.g. regenerating bone marrow). Their effects on the proliferative behaviour of steady-state and regenerating marrow CFU-s, which produce colonies 7, 10 and 12 days post-transplantation have been investigated. The results demonstrate changing sensitivities of CFU-s to inhibitor and stimulator as they progress through a developmental age structure, 'Older' CFU-s (producing early spleen colonies) are more sensitive to stimulator, 'Younger' CFU-s (producing late spleen colonies) are more sensitive to inhibitor.
E G Wright, and
S A Lorimore, and
B I Lord
November 1990,
Cell and tissue kinetics,
E G Wright, and
S A Lorimore, and
B I Lord
January 1986,
Lymphokine research,
E G Wright, and
S A Lorimore, and
B I Lord
October 1968,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E G Wright, and
S A Lorimore, and
B I Lord
January 1978,
Blood cells,
E G Wright, and
S A Lorimore, and
B I Lord
May 1986,
Cell and tissue kinetics,
E G Wright, and
S A Lorimore, and
B I Lord
January 1964,
Proceedings of the National Academy of Sciences of the United States of America,
E G Wright, and
S A Lorimore, and
B I Lord
July 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E G Wright, and
S A Lorimore, and
B I Lord
July 1981,
Cell and tissue kinetics,
E G Wright, and
S A Lorimore, and
B I Lord
September 1984,
British journal of cancer,
E G Wright, and
S A Lorimore, and
B I Lord
August 1973,
British journal of haematology,
