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Lymph node biopsies of 12 patients at high risk for acquired immunodeficiency syndrome (AIDS) with generalized lymphadenopathy (AIDS-related complex [ARC]) and seven controls with conventional lymph node hyperplasia were examined by light microscopy and immunohistochemical staining of frozen tissue. The immunohistochemical results were quantified by planimetric means. Our findings show that the T helper/T suppressor-cytotoxic (Th/Tsc) ratio in lymph nodes from ARC patients is significantly decreased with respect to controls and that this decrease precedes the change in the Th/Tsc ratio in peripheral blood. Our findings distinguish between lymphadenopathy from patients with ARC and other forms of hyperplasia; the relation to AIDS is discussed.
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
November 1983,
American journal of clinical pathology,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
September 1990,
The Laryngoscope,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
March 1993,
Chest,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
February 1984,
European journal of clinical microbiology,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
January 1987,
JAMA,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
March 1992,
JAMA,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
July 1985,
Clinical chemistry,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
May 1992,
Seminars in liver disease,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
January 1987,
Revista paulista de medicina,
M Raphael, and
P Pouletty, and
M Cavaille-Coll, and
W Rozenbaum, and
A Homond, and
L Nonnenmacher, and
A Delcourt, and
J C Gluckman, and
P Debre
November 1988,
Archives of otolaryngology--head & neck surgery,
