BIOMAT Database Logo BIOMAT Database Logo

Effect of long-term proton pump inhibitors on phosphocalcium metabolism and bone mineral density. 2024

Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Department of Gastroenterology & Hepatology, Hedi Chaker University Hospital, Sfax, Tunisia.

Aim: Although Proton pump inhibitors (PPIs) are well-tolerated, their long-term use may be associated with decreased bone mass. Methods: This is a case-control study including patients treated with PPIs (>1 year) and control subjects who have not received PPIs treatment. Results: A total of 90 patients and 90 matched controls were included. PPIs use was associated with hypocalcemia and hypomagnesemia. Vitamin D3 deficiency and hyperparathyroidism were associated with PPIs use. Long-term PPIs use was significantly associated with decreased bone density. Risk factors of decreased bone mineral density (BMD) included age >50 years, menopause, lack of sun exposure, double PPIs dose, daily intake, post-meal intake and association with a mucoprotective agent. Conclusion: Our results highlight the risk of decreased BMD in patients on long-term PPIs treatment.

UI MeSH Term Description Entries

Related Publications

Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Effect of long-term proton pump inhibitors on bone mineral density.
March 2018, La Tunisie medicale,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Proton pump inhibitors use and change in bone mineral density.
September 2016, International journal of rheumatic diseases,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Proton pump inhibitors do not induce change in bone mineral density in a long-term observational study.
October 2013, Evidence-based medicine,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Long-term therapy with proton pump inhibitors is associated with decreased bone density.
May 2009, Medical hypotheses,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Fracture risk and bone mineral density reduction associated with proton pump inhibitors.
January 2012, Pharmacotherapy,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
The Association Between Prolonged Proton Pump Inhibitors Use and Bone Mineral Density.
January 2019, Risk management and healthcare policy,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Effect of proton pump inhibitors on bone mineral density: A systematic review and meta-analysis of observational studies.
December 2020, Bone reports,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Proton pump inhibitors, bone and phosphocalcic metabolism.
March 2024, Joint bone spine,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Correlation of Bone Mineral Density Scores and Proton Pump Inhibitors Use in the Elderly.
January 2016, Current rheumatology reviews,
Hend Smaoui, and Lassaad Chtourou, and Dana Jallouli, and Samar Ben Jemaa, and Iheb Karaa, and Mouna Boudabbous, and Manel Moalla, and Hela Gdoura, and Leila Mnif, and Ali Amouri, and Rim Akrout, and Fatma Ayadi, and Sofien Baklouti, and Nabil Tahri
Correlation of Bone Mineral Density Scores and Proton Pump Inhibitors Use in the Elderly.
March 2016, Current rheumatology reviews,
Copied contents to your clipboard!