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We have cloned CDC9, the structural gene for Saccharomyces cerevisiae DNA ligase, and investigated its transcriptional regulation both as a function of cell cycle stage and after UV irradiation. The steady-state level of DNA ligase mRNA increases at least fourfold in late G1, after the completion of start but before S phase. This high level of CDC9 mRNA then decays with an apparent half-life of ca. 20 min and remains at a low basal level throughout the rest of the cell cycle. The accumulation of CDC9 mRNA in late G1 is dependent upon the completion of start but not the CDC7 and CDC8 functions. Exposure of cells to UV light elicits an eightfold increase in DNA ligase mRNA levels.
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
December 1992,
Biochemistry,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
August 1978,
Nature,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
February 1979,
Molecular & general genetics : MGG,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
August 1983,
European journal of biochemistry,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
May 1991,
Molecular and cellular biology,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
January 1985,
Molecular & general genetics : MGG,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
October 1999,
Current biology : CB,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
October 1982,
Current genetics,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
December 1985,
Nucleic acids research,
T A Peterson, and
L Prakash, and
S Prakash, and
M A Osley, and
S I Reed
September 1994,
FEBS letters,
