-transparent.png){kind=logo}
Immunity to colorectal cancer antigen was tested by the tube leukocyte adherence inhibition (LAI) assay, using spent medium of human carcinoma cell lines as a source of antigen. The assay was positive in 18 out of 43 patients (41%) with colorectal tumor in comparison to only 2 out of 34 (5.8%) of colorectal cancer patients clinically free of disease, and to 4 out of 150 (2.6%) healthy subjects. The frequency of positive results correlated negatively with the tumor burden, 16 out of 29 (55.1%) patients with Dukes' A, B and C being positive compared to only 2 out of 14 (14.2%) patients with Dukes' stage D disease. Addition of PGE2 enhanced the sensitivity of the assay without affecting its specificity. The number of positive assays increased from 18 to 32 (41.8% to 74.4%) in the whole group of 43 colorectal cancer patients without altering significantly the frequency of positive results in the control group. The results with all groups of patients were influenced similarly by the addition of prostaglandins, the frequency of positive assays increasing from 55.1% to 82.7% and from 14.1% to 57.1% in early and advanced disease, respectively. These results lend further support to the value of the LAI assay in diagnosis and monitoring of the immune response in human colorectal cancer.
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
September 1976,
International journal of cancer,
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
April 1981,
Rinsho byori. The Japanese journal of clinical pathology,
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
March 1979,
Cancer,
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
March 1982,
Cancer,
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
October 1987,
Immunology letters,
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
May 1978,
Lancet (London, England),
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
January 1980,
Journal of immunological methods,
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
February 1979,
Cancer research,
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
June 1983,
International journal of cancer,
A Fink, and
A Shani, and
Z Weisman, and
U Wechsler, and
R Pfeffermann, and
N Harpaz, and
S Eitan, and
Z Bentwich
January 1982,
Zeitschrift fur medizinische Laboratoriumsdiagnostik,
