A simple method for measurement of intestinal calcium absorption in humans by double-isotope technique. 1985

M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier

We describe a method for the fast calculation of total fractional calcium absorption (TFCaA) by the double-isotope technique (45Ca orally and 47Ca intravenously). The gamma- and beta-activities of plasma or urine samples were measured simultaneously. 47Ca activity was obtained by a gamma-ray spectrometer after exclusion of scandium 47. The 45Ca activity was measured directly by subtracting the 47Ca plus 47Sc component from the total beta-activity. In addition, 45Ca activity was determined after 8 weeks, to allow for 47Ca and 47Sc decay. There was good correlation between these two methods of measuring 45Ca activity. TFCaA was calculated both by deconvolution taken as a reference method and from the equilibrium quotient 45Ca/47Ca observed in several blood or urine samples collected at different times. The most convenient sampling time for calculation of this ratio was reappraised, taking into account the type of solution ingested orally (water or milk). The results indicate that simultaneous counting of gamma- and beta-activities of an appropriate plasma or urine sample provides a good and rapid measure of the calcium absorption. This method is considered to be useful as a clinical tool.

UI MeSH Term Description Entries
D007408 Intestinal Absorption Uptake of substances through the lining of the INTESTINES. Absorption, Intestinal
D008297 Male Males
D011865 Radioisotope Dilution Technique Method for assessing flow through a system by injection of a known quantity of radionuclide into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed) Radioisotope Dilution Technic,Dilution Technic, Radioisotope,Dilution Technics, Radioisotope,Dilution Technique, Radioisotope,Dilution Techniques, Radioisotope,Radioisotope Dilution Technics,Radioisotope Dilution Techniques,Technic, Radioisotope Dilution,Technics, Radioisotope Dilution,Technique, Radioisotope Dilution,Techniques, Radioisotope Dilution
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002132 Calcium Radioisotopes Unstable isotopes of calcium that decay or disintegrate emitting radiation. Ca atoms with atomic weights 39, 41, 45, 47, 49, and 50 are radioactive calcium isotopes. Radioisotopes, Calcium
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
November 1965, The Journal of laboratory and clinical medicine,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
January 1984, The British journal of nutrition,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
January 1978, Medecine & chirurgie digestives,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
January 1975, The Netherlands journal of medicine,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
January 1970, Calcified tissue research,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
January 1973, Srpski arhiv za celokupno lekarstvo,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
November 1965, British journal of haematology,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
July 1974, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
January 2011, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA,
M Griessen, and A Jung, and B Cochet, and P Bartholdi, and J M Gaspoz, and F Infante, and A Donath, and E Loizeau, and B Courvoisier
September 1980, Clinical science (London, England : 1979),
Copied contents to your clipboard!