Significance of HLA matching in renal transplantation. A prospective one-center study of 485 transplants matched or mismatched for HLA-A, B, C, D, and DR antigens. 1979

D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby

Matching for HLA haplotypes as well as for HLA-A and B antigens improved graft survival in 112 living related first transplants. In cadaveric first transplants, matching for HLA-A and B antigens had a beneficial effect on the fate of 373 grafts, while matching for HLA-C antigens had no predictive value. One hundred seventeen cadaveric transplants and their recipients were prospectively typed for the HLA-DR antigens. Compatibility for HLA-DR was found to be prognostically beneficial irrespective of matching for HLA-A and B antigens, and with no difference between transfused and nontransfused patients. Matching both for HLA-A , B and D/DR was thus found to influence the outcome of renal transplantation.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D002102 Cadaver A dead body, usually a human body. Corpse,Cadavers,Corpses
D006650 Histocompatibility Testing Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed) Crossmatching, Tissue,HLA Typing,Tissue Typing,Crossmatchings, Tissue,HLA Typings,Histocompatibility Testings,Testing, Histocompatibility,Testings, Histocompatibility,Tissue Crossmatching,Tissue Crossmatchings,Tissue Typings,Typing, HLA,Typing, Tissue,Typings, HLA,Typings, Tissue
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014184 Transplantation, Homologous Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals. Transplantation, Allogeneic,Allogeneic Grafting,Allogeneic Transplantation,Allografting,Homografting,Homologous Transplantation,Grafting, Allogeneic
D016030 Kidney Transplantation The transference of a kidney from one human or animal to another. Grafting, Kidney,Renal Transplantation,Transplantation, Kidney,Transplantation, Renal,Kidney Grafting,Kidney Transplantations,Renal Transplantations,Transplantations, Kidney,Transplantations, Renal

Related Publications

D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
October 1980, The New England journal of medicine,
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
December 1992, Transplantation proceedings,
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
March 1983, The Journal of urology,
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
November 1978, Lancet (London, England),
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
March 1981, Transplantation proceedings,
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
April 1979, Transplantation,
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
January 1981, Scandinavian journal of urology and nephrology. Supplementum,
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
July 2001, Kidney international,
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
June 1978, Lancet (London, England),
D Albrechtsen, and A Bratlie, and E Kiss, and B G Solheim, and A B Thoresen, and N Winther, and E Thorsby
July 1984, Transplantation,
Copied contents to your clipboard!