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In a preliminary communication we reported that mebendazole, a vermicide, decreased plasma glucose and free fatty acid concentrations and increased plasma C peptide concentrations in both type II diabetic patients. Therefore, we suggested that mebendazole was an insulin secretagogue. However, these were uncontrolled studies, and improved metabolic control in these patients due to spontaneous remission rather than drug-induced insulin secretion was a possibility. To investigate the direct effect of mebendazole on insulin secretion we used intact islets isolated from normal rat pancreata. Mebendazole in concentrations as low as 10 to 20 mumol/L caused a twofold to threefold increase in acute-phase insulin release from isolated perifused rat islets. This heightened insulin release occurred in the presence of glucose-stimulated insulin secretion.
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
June 1986,
The Journal of pharmacology and experimental therapeutics,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
September 1994,
Acta diabetologica,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
January 1986,
Experientia,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
March 1976,
The Journal of clinical investigation,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
January 1990,
Diabetes,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
October 1986,
Diabetes,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
March 1979,
Diabetes,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
October 1989,
The American journal of physiology,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
February 1998,
Diabetes,
O E Owen, and
R H Smith, and
S Caprio, and
M A Mozzoli, and
A K Rao, and
G Litwack, and
T K Ray, and
G Boden
December 1993,
British journal of anaesthesia,
