-transparent.png){kind=logo}
SEWA tumour cells are derived from an osteosarcoma induced in an A.SW mouse by infection with polyoma virus. Cytogenetic analyses have revealed three different characteristic chromosomal abnormalities diagnostic for the presence of amplified genes: 'double minutes' (DMs), homogeneously staining chromosomal regions (HSRs) and C-bandless chromosomes (CMs; for review see ref. 2). DMs may undergo fluctuation in number depending on the conditions in which the cells grow. Their number usually increases after injection of cells into a mouse and often is reduced to undetectable levels when the cells are explanted back into tissue culture; when the cells are re-introduced into the mouse, they again acquire multiple DMs. We show here that cells of SEWA lines carrying DMs, HSRs or CMs contain amplified copies of the proto-oncogene c-myc and enhanced levels of c-myc messenger RNA and c-myc protein. DMs or CMs are the sites of c-myc amplification in two different SEWA lines.
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
October 1988,
Oncogene,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
February 1985,
Molecular and cellular biology,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
March 1994,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
January 1983,
Nature,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
January 1985,
Nature,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
April 1990,
Pathology, research and practice,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
December 1992,
Diagnostic molecular pathology : the American journal of surgical pathology, part B,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
September 1984,
Gan,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
December 1988,
Journal of surgical oncology,
M Schwab, and
G Ramsay, and
K Alitalo, and
H E Varmus, and
J M Bishop, and
T Martinsson, and
G Levan, and
A Levan
June 1994,
Cancer letters,
