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The effects of the antiaggregant substance ticlopidine and of the anticoagulant acenocoumarol on patency rates of aorto-coronary bypass grafts were compared in a prospective randomized trial. Ticlopidine, 250 mg b.i.d. was administered orally from the first postoperative day till angiography, while anticoagulation with acenocoumarol was initiated on the second to third postoperative day. Side-effects of ticlopidine were rare and patient management with the standard dosage of this drug was easier than oral anticoagulation. From an initial group of 166 randomized patients 149 completed the trial by coronary angiography three months postoperatively. The 78 patients in the ticlopidine group showed a compliance of 85%. The average prothrombin time in the 71 patients receiving acenocoumarol was 26.9%. Detailed statistical analysis of the two study groups revealed no reason to doubt the correctness of randomization. Coronary angiography showed an average patency rate per patient of 84% with ticlopidine and of 82% with acenocoumarol. This and various other measures of graft occlusion did not reveal any substantial difference in graft patency of patients receiving ticlopidine or acenocoumarol. It is concluded that ticlopidine may well be used instead of anticoagulants for prevention of postoperative occlusion of aorto-coronary bypass grafts.
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
December 1990,
The American journal of cardiology,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
October 1972,
The Journal of thoracic and cardiovascular surgery,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
January 1986,
European heart journal,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
April 1976,
Circulation,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
January 1980,
Connecticut medicine,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
January 1974,
Cardiology,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
March 1974,
The Journal of cardiovascular surgery,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
January 1996,
Folia morphologica,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
June 1986,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
M E Rothlin, and
N Pfluger, and
K Speiser, and
N Goebel, and
H P Krayenbühl, and
W Steinbrunn, and
M Turina, and
A Senning
June 1974,
The American journal of cardiology,
