-transparent.png){kind=logo}
In 104 patients undergoing anaesthesia of short duration, two different solvents, propylene glycol and cremophor, were compared in a double-blind trial. Diazepam 10 mg in a coded solution was injected into a superficial vein of the hand using a small-gauge needle. The vein was examined after 14 days. The frequency of thrombophlebitis with propylene glycol was 62.2% and with cremophor 3.4% (P less than 0.001). The frequency of pain on injection was also in favour of the new solvent (P less than 0.001). The possibility of anaphylactic reactions accredited to cremophor, however, restricts the use of the new injection.
Related Publications
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
January 1980,
British journal of anaesthesia,
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
June 1981,
Journal of the American Dental Association (1939),
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
July 1974,
British medical journal,
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
September 1980,
Journal of the American Dental Association (1939),
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
January 1973,
JAMA,
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
January 1988,
Indian journal of physiology and pharmacology,
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
September 1973,
JAMA,
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
April 1982,
Journal of the Royal Society of Medicine,
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
October 1981,
British dental journal,
M A Mattila, and
M Ruoppi, and
M Korhonen, and
H M Larni, and
L Valtonen, and
H Heikkinen
July 1981,
British dental journal,
