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A multicentre double-blind crossover study of tiaprofenic acid 600 mg daily against indomethacin 75 mg daily was carried out in 68 patients with rheumatoid arthritis to compare short-term efficacy and tolerance. There were no significant differences in efficacy between the two treatments, but significantly fewer C.N.S. side-effects were associated with tiaprofenic acid treatment. Five patients withdrew during the course of the study due to side-effects and all were receiving indomethacin.
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