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We studied the production and secretion of immunoglobulin by tumor cells in two patients with nonsecretory myeloma, by means of an immunoperoxidase technique and plaque-forming cell assay. Immunoperoxidase staining of bone marrow cells revealed monoclonal proliferation of immunoglobulin-containing cells, and the plaque-forming cell assay of peripheral mononuclear cells and bone marrow cells showed secretion of monoclonal immunoglobulin from the myeloma cells. These observations suggest that the secreted protein disappears as a result of enhanced catabolism or rapid deposition. There has been speculation as to the existence of this type of nonsecretory myeloma, but there had been no evidence. We were able to demonstrate it with the plaque-forming cell assay.
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
January 1991,
The Journal of the Egyptian Public Health Association,
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
June 1974,
Harefuah,
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
December 1977,
The American journal of medicine,
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
May 1984,
Journal of the American Veterinary Medical Association,
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
December 1999,
Hematology/oncology clinics of North America,
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
November 1976,
Journal of clinical microbiology,
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
March 1984,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
January 2014,
Internal medicine (Tokyo, Japan),
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
September 1978,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
H Matsuzaki, and
T Kagimoto, and
S Matsushita, and
M Matsuoka, and
H Tajima, and
F Yamamura, and
K Takatsuki
December 1972,
American journal of clinical pathology,
