Biomaterial Database

In-vivo bactericidal activity of Sch 34343 in Bacteroides fragilis abscesses and in Bacteroides fragilis-Escherichia coli abscesses. 1985

C L Wells, and L A Arland, and R L Simmons, and O D Rotstein

Bacteroides fragilis pure-culture abscesses and Bact. fragilis-Escherichia coli mixed-culture abscesses were initiated subcutaneously in mice and intraperitoneally in rats. Within 1 h after injection of Sch 34343, the drug was present in higher concentrations in the abscesses than in the blood of infected animals. After five days of Sch 34343 therapy with either 100 or 400 mg/kg administered five times a day to mice with subcutaneous abscesses, the numbers of Bact. fragilis in pus decreased approximately three log-fold, reflecting a killing of 99.99% of the viable Bact. fragilis, while the numbers of E. coli decreased approximately 0.5 log-fold, reflecting a killing of 50% of the viable E. coli. After five days of therapy with either 50 or 150 mg/kg administered five times a day to rats with intraperitoneal fibrin clot abscesses, the viable Bact. fragilis again decreased three log-fold; the viable E. coli decreased one log-fold in rats given the higher dosages of the drug. Sch 34343 is a promising agent for the treatment of anaerobic infections because it can penetrate into anaerobic abscesses and can kill large numbers of bacteria within abscesses.

UI	MeSH Term	Description	Entries
D007769	Lactams	Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.	Lactam,Lactim,Lactims
D008297	Male		Males
D010532	Peritoneal Diseases	Pathological processes involving the PERITONEUM.	Peritoneal Disease
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D004334	Drug Administration Schedule	Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.	Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004926	Escherichia coli	A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.	Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D004927	Escherichia coli Infections	Infections with bacteria of the species ESCHERICHIA COLI.	E coli Infections,E. coli Infection,Infections, E coli,Infections, Escherichia coli,E coli Infection,E. coli Infections,Escherichia coli Infection,Infection, E coli,Infection, E. coli,Infection, Escherichia coli
D005260	Female		Females
D000038	Abscess	Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.	Abscesses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia