A new method for the detection of fecal occult blood was tested in a clinical setting. The test is performed by placing a chemically treated paper pad in the toilet bowl after a bowel movement and observing for color change on the pad. This method eliminates the mechanical task of handling or gathering stool by the patient. Forty-four valid trials were completed in 19 patients with known risk factors for gastrointestinal disease. A widely used reference standard (Hemoccult II) was utilized as a control method against which the study method was compared. Concordance of the results of the study method was noted in 95.8 percent of positive cases and 100 percent of negative cases. This preliminary study supports further investigation. If the aesthetic aspects of fecal occult blood testing can be improved, there may be improvements in patient compliance with screening protocols for the early detection of colorectal cancer.